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In Tryptamine Palace, James Oroc notes that obtaining an optimal dose when using tobacco is very best modified in two mg increments. He also explains that acquiring your “minimum powerful dose” allows you actually don't forget the transcendental encounter.
In addition there are issues about mixing it with ayahuasca, with at least just one death described in the literature.
When taken orally with the MAOI, the effects take for a longer time to onset (about 30 minutes to an hour) and final for about 4 to 6 hrs.
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